The problem of embryo implantation failure cannot be ignored

Many women have realized their dream of being a mother through IVF technology, but there are still many people on the way to beg for a child. Some patients have even undergone multiple IVF treatment cycles, all of which ended in failure.

What cannot be ignored is thatAlthough many people have transplanted embryos with normal chromosomes and morphology, they still fail to get pregnant after transplantation.

Statistics found thatApproximately 74% of failed assisted reproduction cycles are due to the failure of the embryo to implant successfully.

Is there a problem with the "seeding" time?

In addition to embryos, another key factor for successful pregnancy through IVF treatment is the timing of embryo transfer.

During most of the menstrual cycle, the endometrium is in a non-acceptable state (that is, it cannot accept an embryo).There is only a short period of time that the endometrium can accept embryos. This period is the receptive period and is also vividly called the "planting window".

Just like seeds, if you sown in the wrong season, no matter how good the seeds are, they cannot take root and sprout.If the embryo transfer is not performed when the endometrium is in the "implantation window", the probability of implantation failure will increase.

What is Endometrial Receptivity Analysis Test (ERA)?

Simply put, ERA is a testing service.It analyzes the expression of 248 genes related to endometrial receptivity to determine the receptive status of the endometrium at the time of sampling, and then finds the patient's individualized "planting window".

Why do we need ERA?

The endometrium can accept embryo implantation only within a certain period of time, which is the tolerant period once a month, which we call"Plant Window".

According to the literature,About 30% of women’s planting window is earlier or later than the regular time, and there are individual differences in the length of the planting window.That is to say, the planting window of every woman is specific to a certain extent.

At this time, if the embryo transfer is carried out according to the regular time, the problem of unsynchronized embryo development and endometrial state will occur, which will lead to the failure of embryo implantation.

InpatientEmbryo transfer through the “planting window” can help assisted reproduction patients greatly increase the chance of pregnancy.

Especially for patients with repeated implantation failures, we should focus on whether the reason for the failure is: the transplantation time does not fall within the "implantation window".But in fact,All women undergoing IVF treatment can use ERA to increase their chances of pregnancy.

references:

• Diaz-Gimeno., et al. A genomic diagnostictool for human endometrial receptivity based on the transcriptomicsignature.Fertil.Steril., 2011.9S:50-60,60. el-15.
  [2] Ruiz-Alonso et al., The endometrialreceptivity analysis for diagnosis and personalized embryo transfer as atreatment for patients with repeated implantation failure. FertilSteril.2013.100(3):818-24.

[3]Clemente-Ciscar et al, 2018, submitted
[4] 2016 ASRM Distinguished Researcher Award

[5]Ruiz-Alonso et al., What a difference twodays make:"personalized" embryo transfer (pET) paradigm: a casereport and pilot study.Hum Reprod.2014.Jun; 29(6):1244-7.

[6]Tan et al., The role of the endometrial receptivity array (ERA) I patients who have failed euploid embryo transfers. JAssist Reprod Genet. 2018 Apr;35(4):683-692. 

American Personalized IVF Clinic