The follicles are big and round, but they can't get pregnant?Something went wrong here! #test tube baby#

Why don't you ovulate?

Such patients are often encountered in reproductive clinics: the normal menstrual cycle is regular, and the follicles are normally developed by multiple B-ultrasound monitoring, but the follicles that do not ovulate and do not ovulate form a "luteinized cyst".Normal ovulation is one of the prerequisites for pregnancy. If there is a problem with ovulation, it will lead to infertility.The follicle grows well, but does not ovulate. This refers to such a disease: luteinized unruptured follicle syndrome (LUFS), as the name suggests, refers to the unruptured follicle, which is luteinized in advance, resulting in ovulation failure.

To put it simply, the process of ovulation requires the help of a hormone called luteinizing hormone (LH). Normally, ovulation occurs 48 hours after the LH peak. Quietly waiting for ovulation, but unable to monitor the release of follicles.

The follicles of these people are luteinized under the action of LH, that is, the follicles are often said to be aging. Ultrasonography found that the elder follicles formed luteinized cysts, and the blood progesterone level was also significantly increased.

LUFS can occur at any time during the menstrual phase, but occurs more frequently during the early and late follicular phases.

Why does LUFS occur?

LUFS is a refractory ovulatory disorder first reported and named by Jewelewicz in 1975.

The incidence of LUFS is 12% ​​in women with normal menstrual cycles and as high as 5% to 25% in infertile women [43]. LUFS may be associated with many conditions, such as unexplained infertility, endometriosis, pelvic adhesions and the use of non-steroidal anti-inflammatory drugs (NSAIDs), etc. Its pathophysiological mechanism has not been fully elucidated, and may be related to endocrine abnormalities, mechanical stimulation and drug application.The use of ovulation induction drugs also increases the incidence of LUFS. 

How is LUFS diagnosed?

The menstrual history of patients with LUFS is very similar to that of normal women, and most patients with LUFS have normal menstrual cycles, so they are easily overlooked.

Diagnosis is mainly based on ultrasonography, which is a simple, effective and non-invasive method.Ultrasound observation of LUFS showed that the size of the follicle increased significantly within 24 hours, or the cyst wall thickened.Serial ultrasonography combined with endocrine hormone determination can quickly and accurately determine the occurrence of LUFS.

Of course, cyst-like echoes on the ovary still need to be differentiated from ovarian cysts, benign or malignant ovarian tumors.

How is LUFS treated?

The incidence of LUFS in infertile women is as high as 25% to 43%.Such a high incidence, how to treat it?How can I successfully conceive a baby?

  1. Psychotherapy

Mental anxiety, or excessive psychological pressure caused by long-term infertility can also lead to the occurrence of LUFS. Therefore, it is necessary to carry out psychological intervention, improve psychological state, and maintain a happy mood, which will also help to smooth ovulation.

  • Treat the primary disease

For patients with recurrent LUFS, common primary diseases need to be excluded and actively treated, for example: LUFS accompanied by hyperprolactinemia, pituitary-related diseases need to be excluded; for patients with endometriosis, adjuvant surgery can be used or drug treatment.

3. Medication

Continuous, dynamic monitoring of follicle development, auxiliary blood hormone measurement or urine LH measurement, when the follicle matures, give human chorionic gonadotropin (HCG) to help ovulation.

For patients with irregular menstrual cycles, follicle-stimulating hormone can also be used to promote follicle growth and development. After the follicles are mature, injection of HCG can help ovulation.Studies have also shown that the application of granulocyte colony-stimulating factor (G-CSF) 24-48 hours before HCG injection can significantly prevent the occurrence of LUFS during ovulation induction.

4. Ultrasound-guided follicular puncture

If the egg cells still do not collapse or disappear 48 hours after the injection of HCG, the follicles can be punctured under the guidance of transvaginal ultrasound, and then intrauterine insemination can be used to assist pregnancy.

This method is quick and effective, but follicle puncture is an invasive procedure that requires infection prevention.

5. In vitro fertilization embryo transfer

If the above treatments are still ineffective, or if LUFS still occurs repeatedly, in vitro fertilization and embryo transfer technology can be used to assist pregnancy to solve the problem of fertility, which is commonly known as test-tube baby. Conjugate and skip the process of ovulation.

Recommended

American concubine

Go all out to create miracles and help the pregnant hero accompany you on your way to beg!

0 comments